abstract：:Historically, the immune response after spinal cord injury was considered largely detrimental owing to the release of neurotoxic factors. While there is validity to this view, there is much greater heterogeneity of immune cells than was previously realized. Associated with this heterogeneity of immune cell subtypes, t...

journal_title：Experimental neurology

authors： Plemel JR,Wee Yong V,Stirling DP

更新日期：2014-08-01 00:00:00

abstract：:Falls are a major source of hospitalization, long-term institutionalization, and death in older adults and patients with Parkinson's disease (PD). Limited attentional resources are a major risk factor for falls. In this review, we specify cognitive-behavioral mechanisms that produce falls and map these mechanisms onto...

journal_title：Experimental neurology

authors： Sarter M,Albin RL,Kucinski A,Lustig C

更新日期：2014-07-01 00:00:00

abstract：:Grafting fetal striatal cells into the brain of Huntington's disease (HD) patients has raised certain expectations in the past decade as an effective cell-based-therapy for this devastating condition. We argue that the first requirement for successful transplantation is defining the window of plasticity for the striat...

journal_title：Experimental neurology

authors： Sarchielli E,Marini M,Ambrosini S,Peri A,Mazzanti B,Pinzani P,Barletta E,Ballerini L,Paternostro F,Paganini M,Porfirio B,Morelli A,Gallina P,Vannelli GB

更新日期：2014-07-01 00:00:00

abstract：:Despite the importance of the periaqueductal gray (PAG) in the modulation of nociception and pain, many aspects of the roles of the different columns of the PAG in descending controls: facilitation and inhibition, are not understood. Employing a tonic muscle pain model established by i.m. injection of 5.8% saline into...

journal_title：Experimental neurology

authors： Lei J,Sun T,Lumb BM,You HJ

更新日期：2014-07-01 00:00:00

abstract：:Diffuse noxious inhibitory controls (DNIC) are very powerful long-lasting descending inhibitory controls which are pivotal in modulating the activity of spinal and trigeminal nociceptive neurons. DNIC are subserved by a loop involving supraspinal structures such as the lateral parabrachial nucleus and the subnucleus r...

journal_title：Experimental neurology

authors： Chebbi R,Boyer N,Monconduit L,Artola A,Luccarini P,Dallel R

更新日期：2014-06-01 00:00:00

abstract：:Chemotherapy-related cognitive deficits are a major neurological problem, but the underlying mechanisms are unclear. The death of neural stem/precursor cell (NSC) by cisplatin has been reported as a potential cause, but this requires high doses of chemotherapeutic agents. Cisplatin is frequently used in modern oncolog...

journal_title：Experimental neurology

authors： Andres AL,Gong X,Di K,Bota DA

更新日期：2014-05-01 00:00:00

abstract：:The GluN2 subunits that compose N-methyl-d-aspartate receptors (NMDARs) are attractive drug targets for therapeutic intervention in several diseases, in particular Parkinson's disease (PD). The precise roles and possible dysfunctions of NMDARs attributed to specific GluN2 subunits are however unresolved. Through the u...

journal_title：Experimental neurology

authors： Feng ZJ,Zhang X,Chergui K

更新日期：2014-05-01 00:00:00

abstract：:The role of type IIA receptor protein tyrosine phosphatases (RPTPs), which includes LAR, RPTPσ and RPTPδ, in the nervous system is becoming increasingly recognized. Evidence supports a significant role for these RPTPs during the development of the nervous system as well as after injury, and mutations in RPTPs are asso...

journal_title：Experimental neurology

authors： Yi JH,Katagiri Y,Yu P,Lourie J,Bangayan NJ,Symes AJ,Geller HM

更新日期：2014-05-01 00:00:00

abstract：:Assessing the efficacy of human stem cell transplantation in rodent models is complicated by the significant immune rejection that occurs. Two recent reports have shown conflicting results using neonatal tolerance to xenografts in rats. Here we extend this approach to mice and assess whether neonatal tolerance can pre...

journal_title：Experimental neurology

authors： Mattis VB,Wakeman DR,Tom C,Dodiya HB,Yeung SY,Tran AH,Bernau K,Ornelas L,Sahabian A,Reidling J,Sareen D,Thompson LM,Kordower JH,Svendsen CN

更新日期：2014-04-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) is produced by the choroid plexus and moved by multi-ciliated ependymal cells through the ventricular system of the vertebrate brain. Defects in the ependymal layer functionality are a common cause of hydrocephalus. N-WASP (Neural-Wiskott Aldrich Syndrome Protein) is a brain-enriched regulato...

journal_title：Experimental neurology

authors： Jain N,Lim LW,Tan WT,George B,Makeyev E,Thanabalu T

更新日期：2014-04-01 00:00:00

abstract：:We assessed whether the protective action of progesterone on traumatic brain injury (TBI) could be influenced by the consumption of omega-3 fatty acids during early life. Pregnant Sprague-Dawley rats were fed on omega-3 adequate or deficient diet from 3rd day of pregnancy and their female offspring were kept on the sa...

journal_title：Experimental neurology

authors： Tyagi E,Agrawal R,Ying Z,Gomez-Pinilla F

更新日期：2014-03-01 00:00:00

abstract：:Astrocytes react to CNS injury by building a dense wall of filamentous processes around the lesion. Stromal cells quickly take up residence in the lesion core and synthesize connective tissue elements that contribute to fibrosis. Oligodendrocyte precursor cells proliferate within the lesion and entrap dystrophic axon ...

journal_title：Experimental neurology

authors： Cregg JM,DePaul MA,Filous AR,Lang BT,Tran A,Silver J

更新日期：2014-03-01 00:00:00

abstract：:Peripheral neuropathy (PN) is a debilitating and dose-limiting side effect of treatment with the chemotherapeutic agent, paclitaxel. Understanding the effects of paclitaxel on sensory neuronal function and the signaling pathways which mediate these paclitaxel-induced changes in function are critical for the developmen...

journal_title：Experimental neurology

authors： Pittman SK,Gracias NG,Vasko MR,Fehrenbacher JC

更新日期：2014-03-01 00:00:00

abstract：:Recent studies have shown that hemorrhagic injury in the preterm cerebellum leads to long-term neurological sequelae, such as motor, affective, and cognitive dysfunction. How cerebellar hemorrhage (CBH) affects the development and function of the cerebellum is largely unknown. Our study focuses on developing a mouse m...

journal_title：Experimental neurology

authors： Yoo JY,Mak GK,Goldowitz D

更新日期：2014-02-01 00:00:00

abstract：:Ghrelin has been shown to regulate neurogenesis in the hippocampus. The aim of this study was to investigate the possible influence of ghrelin on cell proliferation and neuroblast formation in the subventricular zone (SVZ) and rostral migratory system (RMS) and generation of interneurons in the olfactory bulb (OB). We...

journal_title：Experimental neurology

authors： Li E,Kim Y,Kim S,Sato T,Kojima M,Park S

更新日期：2014-02-01 00:00:00

abstract：:Ibuprofen is commonly used as an anti-inflammatory analgesic drug, although it is not amongst the first-line treatments for neuropathic pain. Its main effects are mediated by non-specific inhibition of COX enzymes, but it also exerts some COX-independent effects, such as the inhibition of RhoA signaling and the modula...

journal_title：Experimental neurology

authors： Redondo-Castro E,Navarro X

更新日期：2014-02-01 00:00:00

abstract：:Mitochondria actively participate in neurotransmission by providing energy (ATP) and maintaining normative concentrations of reactive oxygen species (ROS) in both presynaptic and postsynaptic elements. In human and animal epilepsies, ATP-producing respiratory rates driven by mitochondrial respiratory complex (MRC) I a...

journal_title：Experimental neurology

authors： Simeone KA,Matthews SA,Samson KK,Simeone TA

更新日期：2014-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by a prominent loss of nigrostriatal dopamine (DA) neurons with an accompanying neuroinflammation. The peptide angiotensin II (AngII) plays a role in oxidative-stress induced disorders and is thought to mediate its detrimental actions v...

journal_title：Experimental neurology

authors： Sonsalla PK,Coleman C,Wong LY,Harris SL,Richardson JR,Gadad BS,Li W,German DC

更新日期：2013-12-01 00:00:00

abstract：:Sulforaphane (SFN) is an organosulfur compound present in vegetables and has potent anti-oxidant and anti-inflammatory activities. This study was aimed at investigating the effect of treatment with SFN on inflammation and oxidative stress, and the potential mechanisms underlying the action of SFN in experimental autoi...

journal_title：Experimental neurology

authors： Li B,Cui W,Liu J,Li R,Liu Q,Xie XH,Ge XL,Zhang J,Song XJ,Wang Y,Guo L

更新日期：2013-12-01 00:00:00

abstract：:Olfactomedin 1 (Olfm1) is a secreted glycoprotein that is preferentially expressed in neuronal tissues. Here we show that deletion of exons 4 and 5 from the Olfm1 gene, which encodes a 52 amino acid long region in the N-terminal part of the protein, increased neonatal death and reduced body weight of surviving homozyg...

journal_title：Experimental neurology

authors： Nakaya N,Sultana A,Munasinghe J,Cheng A,Mattson MP,Tomarev SI

更新日期：2013-12-01 00:00:00

abstract：:Purkinje neurons are a sensitive and specialised cell type important for fine motor movement and coordination. Purkinje cell damage manifests as motor incoordination and ataxia - a prominent feature of many human disorders including spinocerebellar ataxia and Huntington's disease. A correlation between Purkinje degene...

journal_title：Experimental neurology

authors： Cops EJ,Sashindranath M,Daglas M,Short KM,da Fonseca Pereira C,Pang TY,Lijnen RH,Smyth IM,Hannan AJ,Samson AL,Medcalf RL

更新日期：2013-11-01 00:00:00

abstract：:In this study, we examined modulations in phosphatase and tensin homolog (PTEN) and mammalian target of rapamycin (mTOR) protein expression after a lateral C2 hemisection and subsequent intermittent hypoxia (IH) exposure and training, which initiates respiratory motor plasticity and recovery. PTEN and mTOR are signifi...

journal_title：Experimental neurology

authors： Gutierrez DV,Clark M,Nwanna O,Alilain WJ

更新日期：2013-10-01 00:00:00

abstract：:Parkinson's disease (PD) is an aging-associated neurodegenerative disorder with progressive pathology involving the loss of midbrain dopaminergic neurons. Neurotrophic factors are promising for PD gene therapy; they are integrally involved in the development of the nigrostriatal system. Cerebral dopamine neurotrophic ...

journal_title：Experimental neurology

authors： Ren X,Zhang T,Gong X,Hu G,Ding W,Wang X

更新日期：2013-10-01 00:00:00

abstract：:The control of gene expression by miRNAs has been widely investigated in different species and cell types. Following a probabilistic rather than a deterministic regimen, the action of these short nucleotide sequences on specific genes depends on intracellular concentration, which in turn reflects the balance between b...

journal_title：Experimental neurology

authors： Kinjo ER,Higa GS,de Sousa E,Casado OA,Damico MV,Britto LR,Kihara AH

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The pathogenesis of pain in irritable bowel syndrome (IBS) is poorly understood and treatment remains difficult. We have previously reported that TTX-resistant (TTX-R) sodium channels in colon-specific dorsal root ganglion (DRG) neurons were sensitized and the expression of the endogenous hydrogen sulfide pr...

journal_title：Experimental neurology

authors： Hu S,Xu W,Miao X,Gao Y,Zhu L,Zhou Y,Xiao Y,Xu GY

更新日期：2013-10-01 00:00:00

abstract：:Noninvasive, targeted drug delivery to the brain can be achieved using transcranial focused ultrasound (FUS), which transiently increases the permeability of the blood-brain barrier (BBB) for localized delivery of therapeutics from the blood to the brain. Previously, we have demonstrated that FUS can deliver intraveno...

journal_title：Experimental neurology

authors： Jordão JF,Thévenot E,Markham-Coultes K,Scarcelli T,Weng YQ,Xhima K,O'Reilly M,Huang Y,McLaurin J,Hynynen K,Aubert I

更新日期：2013-10-01 00:00:00

abstract：:CNS damage often results in demyelination of spared axons due to oligodendroglial cell death and dysfunction near the injury site. Although new oligodendroglia are generated following CNS injury and disease, the process of remyelination is typically incomplete resulting in long-term functional deficits. Chondroitin su...

journal_title：Experimental neurology

authors： Pendleton JC,Shamblott MJ,Gary DS,Belegu V,Hurtado A,Malone ML,McDonald JW

更新日期：2013-09-01 00:00:00

abstract：:Abnormal corticostriatal plasticity is a key mechanism of L-DOPA-induced dyskinesia (LID) in Parkinson's disease (PD). Antagonists at glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, such as IEM 1460, reduce induction and expression of dyskinesia in rat and non-human primate models ...

journal_title：Experimental neurology

authors： Kobylecki C,Crossman AR,Ravenscroft P

更新日期：2013-09-01 00:00:00

abstract：:Deep brain stimulation (DBS) has emerged as an important and potentially powerful treatment option for the management of carefully selected patients with advanced Parkinson's disease (PD) who are not adequately controlled by standard medication therapy. Though considerable advances have been made, the mechanisms under...

journal_title：Experimental neurology

authors： Hess CW,Vaillancourt DE,Okun MS

更新日期：2013-09-01 00:00:00

abstract：:Several independent lines of research suggest that disruption of the ubiquitin proteasome system (UPS) may play a role in the pathophysiology of Parkinson's disease. Direct intracerebral injection of UPS inhibitors (e.g. lactacystin) in animals has consistently produced important features of the disease. In this study...

journal_title：Experimental neurology

authors： Mackey S,Jing Y,Flores J,Dinelle K,Doudet DJ

更新日期：2013-09-01 00:00:00

abstract：:Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by a progressive and extensive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and their terminals in the striatum, which results in debilitating movement disorders. This devastating disease affects over 1 m...

journal_title：Experimental neurology

authors： Glavaski-Joksimovic A,Bohn MC

更新日期：2013-09-01 00:00:00

abstract：:Activation of GABA(A) receptors by GABA causes phasic and tonic conductances in different brain areas. In the ventrobasal (VB) thalamus, tonic inhibition originates from GABA acting on extrasynaptic receptors. Here we show that dopamine (DA), the D2-like agonist quinpirole and the selective D4R agonist PD-168,077 decr...

journal_title：Experimental neurology

authors： Yagüe JG,Cavaccini A,Errington AC,Crunelli V,Di Giovanni G

更新日期：2013-09-01 00:00:00

abstract：:A previous study of our group demonstrated that movement performance induced by dopamine agonist drugs in hemiparkinsonian rats unilaterally lesioned with 6-hydroxydopamine (6-OHDA), governs the occurrence of a sensitized motor response to a subsequent dopaminergic challenge (priming model). In the present study, we e...

journal_title：Experimental neurology

authors： Frau L,Morelli M,Simola N

更新日期：2013-09-01 00:00:00

abstract：:The role of 5-HT2 and opioid receptors in pudendal inhibition of bladder activity induced by intravesical infusion of saline or 0.25% acetic acid (AA) was investigated in anesthetized cats using methysergide (a 5-HT2 receptor antagonist) and naloxone (an opioid receptor antagonist). AA irritated the bladder and signif...

journal_title：Experimental neurology

authors： Matsuta Y,Schwen Z,Mally AD,Shen B,Wang J,Roppolo JR,de Groat WC,Tai C

更新日期：2013-09-01 00:00:00

abstract：:In this review we focus on Charcot-Marie-Tooth (CMT) neuropathies and hereditary spastic paraplegias (HSPs). Although these diseases differ in whether they primarily affect the peripheral or central nervous system, both are genetically determined, progressive, long axonopathies that affect motor and sensory pathways. ...

journal_title：Experimental neurology

authors： Timmerman V,Clowes VE,Reid E

更新日期：2013-08-01 00:00:00

abstract：:Axons are the anatomical link between neuronal cell bodies and their target organs, and thus axonal degeneration is the pathological substrate that underlies neurological dysfunction in a large number of neurological conditions. Recent advances in the field of axonal biology demonstrate that axons possess programs for...

journal_title：Experimental neurology

authors： Fischer-Hayes LR,Brotherton T,Glass JD

更新日期：2013-08-01 00:00:00

abstract：:Interest in beta activity in the basal ganglia has mushroomed since it was first identified in the subthalamic nucleus of patients with Parkinson's disease in Jonathan Dostrovsky's landmark paper (Levy et al., 2000). Here we consider a less explored phenomenon; namely gamma frequency synchronisation of neurons in the ...

journal_title：Experimental neurology

authors： Jenkinson N,Kühn AA,Brown P

更新日期：2013-07-01 00:00:00

abstract：:Modification of GABAergic inhibition is an intensely investigated hypothesis guiding research into mechanisms underlying temporal lobe epilepsy (TLE). Seizures can be initiated by blocking γ amino butyric acid type A (GABAA receptors, GABARs), which mediate fast synaptic inhibition in the brain, and controlled by drug...

journal_title：Experimental neurology

authors： Joshi S,Rajasekaran K,Kapur J

更新日期：2013-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Dorsal root ganglia (DRG) sensory neurons cultured from 3 to 5 month streptozotocin (STZ)-induced diabetic rats exhibit structural and biochemical changes seen in peripheral nerve fibers in vivo, including axonal swellings, oxidative damage, reduced axonal sprouting, and decreased NF-κB activity. NF-κB ...

journal_title：Experimental neurology

authors： Saleh A,Schapansky J,Smith DR,Young N,Odero GL,Aulston B,Fernyhough P,Glazner GW

更新日期：2013-03-01 00:00:00

abstract：:Stress is a common environmental factor associated with depressive illness and the amygdala is thought to be integral for this association. For example, repeated stress impairs amygdalar neuroplasticity in rodents and these defects parallel amygdalar deficits in depressive illness patients. Because the excitatory neur...

journal_title：Experimental neurology

authors： Piroli GG,Reznikov LR,Grillo CA,Hagar JM,Fadel JR,Reagan LP

更新日期：2013-03-01 00:00:00